Physical and Transcript Mapping
From WikiGenetics
[edit] Introduction
Mapping of genetic material has given us great insight into the origin of many conditions, and given us ways to examine the risk of developing others. There is a massive amount of DNA in a single cell, and much of it does not actively code for protein. Genetic mapping allows us to find sites of interest within this vast array of material.
Both types of mapping have used extensively to catalogue entire genomes, most famously in the Human Genome Project [1]
[edit] Transcript vs. Physical Mapping
Physical mapping is a procedure that allows us to place genes along the entire genome, and estimate the distance between these sites. Transcript mapping takes the active genes (mRNA) from a specific tissue or cell type, and converts it to DNA in order to learn the role of the gene and its sequence. Both methods serve to help locate genetic markers, and allow us compare these sites in natural DNA and find mutations, additions, or deletions.
[edit] References
- The Human Transcript Map, 1996 (http://www.ncbi.nlm.nih.gov/SCIENCE96/)
- The Human Transcript Map, 1999 (http://www.ncbi.nlm.nih.gov/projects/genome/genemap99/)
